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It's generally more expensive, probably the priciest in South America, especially Patagonia. Budget for hostels and market food to save money, but expect things to cost a little more than you'd hope.
Bogotá is high altitude so expect showers anytime, but Medellín usually stays warm and the rain comes and goes, you'll still get plenty of sunny afternoons.
Looking to book a Uyuni tour, so many companies it's overwhelming. Did anyone have a genuinely good experience with a specific operator they can vouch for?
Definitely take it easy your first day, no big hikes. I found sipping on the coca tea non-stop really helped with the mild dizziness, and keep the ibuprofen handy.